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Robles-Rengel R, Florencio FJ, Muro-Pastor MI

However, in a double-blind placebo-controlled clinical trial on 110 ALS patients, a subcutaneous infusion of NAC (50 mg/kg daily) did not result in a major increase in a 12-month survival or in a reduction of disease progression [156] (Table 2)

A study conducted on the HCT-8 colorectal cell line demonstrated that curcumin increases the sensitivity of 5-FU for the colorectal cell line by downregulating the expression of P-GP and HSP-27, both of which are associated with multidrug-resistant (MDR) proteins [151]

Research is ongoing to expand the range of treatment options and studies have been undertaken to evaluate the use of vitamins (e.g., vitamin E, vitamin B6) and/or supplements (e.g., melatonin, branched chain amino acids) to help manage TD