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Despite the remarkable clinical efficacy of immunotherapies, including immune checkpoint inhibitors (ICIs) and chimeric antigen receptor (CAR)-T cells, across various tumor types, patient responses remain heterogeneous, with some tumors developing resistance through immune evasion strategies

doi: 10.4049/jimmunol.165.12.7199 [DOI] [PubMed] [Google Scholar] 142

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The calcium binding domain may be contained in the subunit sequence, as in K Ca 1, or may be through an additional calcium binding protein such as calmodulin