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Following a toxic dose of APAP, the conjugation pathways of the liver are overwhelmed and an increased proportion of APAP is metabolized by cytochrome (CYP) P450, predominantly CYP2E1, to the highly reactive metabolite NAPQI (Mitchell et al

In addition, several studies have demonstrated that the incorporation of Pongamia-derived bioactive compounds in organic formulations supports sustainable pest management, as karanjin has been shown to function as an efficient pesticide in organic agricultural programs where chemical inputs are restricted ( Pongamia can also form symbiotic associations with mycorrhizal fungi, further enhancing nutrient acquisition and contributing to overall soil health and crop productivity

Remember, minimizing exposure is always preferable to treatment

Overall, these results demonstrated that genistein reduces inflammation, ferroptosis, and the function of SGECs by downregulating ACSL4