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Combined oral contraceptives (COCs) are commonly used off-label to suppress ovarian function and reduce symptoms, though evidence supporting their effectiveness is less robust, with about 50% of patients reporting partial or no symptom improvement

Shisandrin C inhibited MAPK pathway activity in C2C12 skeletal muscle cells, increased antioxidant activity and reduced ROS release, decreasing inflammatory factor levels in these cells by regulating NF-B and Nrf2 translocation to the nucleus

doi: 10.1016/j.psym.2018.05.011 [PubMed] 30346242 Girard TD, Exline MC, Carson SS, et al

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