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10.52336/acm.2021.10.6.02 127 McCormackA

doi: 10.1038/s42255-025-01314-w 18 BarclayK

In vitro and in vivo models have shown that baicalein reduces the impact of IBD by inhibiting the COX-2 activity and decreases the phosphorylation of Ikappa kinase (IKK)- degrading the Ikappa-beta-alfa (I) [69], also ameliorating UC by improving intestinal epithelial barrier via AhR/IL-22 pathway in ILC3s [70] and through the inhibition of TLR4/MyD88 signaling cascade as well as inactivation of NLRP3 inflammasome [71]