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102, 103, 104 Other plasma membrane transporters have been suggested to contribute to the extrusion of CDDP (hence promoting CDDP resistance in preclinical as well as clinical settings), notably ATP-binding cassette, subfamily C (CFTR/MRP), member 2 (ABCC2), best known as multidrug resistance-associated protein 2 (MRP2) 105, 106, 107, 108, 109 and ATPase, class VI, type 11B (ATP11B)

PEG4000 (2.5 g) was added to a beaker and heated to 68 C with continuous stirring until fully melted

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