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Triple-negative breast cancer (~ 15% of all breast cancers) lacks expression of ER, PR, and HER2, making targeted therapies ineffective and resulting in worse survival rates compared to other subtypes [3,4,5]

For chronic tendon injury, hypervascularity and high levels of VEGF were demonstrated in degenerated human and rabbit Achilles tendons or chronic tendon tendinopathy compared to native tendons ( The negative effect may be attributed to the fact that VEGF also has the potential to stimulate the expression of matrix metalloproteinases (MMPs) and inhibit the expression of tissue inhibitors of metalloproteinases (TIMPs) in endothelial cells and fibroblasts ( The Role of Exogenous Vascular Endothelial Growth Factor Delivery in Tendon Healing Due to the necessity of angiogenesis for tendon repair, some scholars have explored the effect of using the delivery of exogenous VEGF on tendon healing as endogenous VEGF may not be sufficient to enhance early revascularization (Table 1

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KLOW targets several stages of the healing cascade inflammation control, angiogenesis, collagen production, and cell migration simultaneously