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Retina sample was fixed for 60 min in 4% PFA at RT and then wash in PBS before preparation for U-ExM

Inflammation It is important to highlight that brain cell damage is not only a consequence of the development of HE but also a contributing factor

NAC has a stronger evidence base than direct glutathione supplementation and is actually used in NHS hospitals for paracetamol overdose due to its ability to replenish hepatic glutathione

The pentameric structure of IgM that provides a high valency to the molecule, and the low affinity of IgM polyreactive natural antibodies, both favor agglutination (100-10,000 times more effective than IgG), which is considered as a paramount component of the IgM-mediated virus neutralization