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Pre-clinical wound-healing models report that GHK-Cu accelerates closure and improves tensile strength through a combination of fibroblast activation, angiogenic signaling, macrophage recruitment, and matrix-protein synthesis

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In intranasal delivery targeting the olfactory mucosa, overcoming the mucus barrier is the first challenge: drugs must dissolve in or traverse the mucus layer before encountering enzymatic degradation or mucociliary clearance (Rassu et al., 2018)