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Accordingly, the probable mechanisms could be discussed in four main approaches, namely, modulation of gut microbiota dysbiosis, production of SCFAs, reduction of gut permeability and metabolic endotoxemia, and regulation of bile acid metabolism ( Evidence has intimated that synbiotics might reverse the detrimental effects of microbiota dysbiosis, promoting weight loss and maintenance via restoring healthy gut microbiota composition and/or function ( Growing evidence has depicted that gut microbiota modification leads to augmented SCFA production, which underlies most of the aforementioned beneficial impacts (58)

MSA-DH dependent formation of D-malate was indicated at a retention time of 18.4 min (yellow line)