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Description

Neutralizing antibody against PAI-1 attenuated p65 activation in IL-1 treated hepatocytes and blocked PAI-1 induction completely, suggesting the freely released PAI-1 is required to fully activate p65 and induce PAI-1

Humanin is an endogenous activator of chaperone-mediated autophagy

Alternatively, different cells (LSCs and HT1080 cells in this case) may have distinct responses to the same stimulation, as has been shown by others 41