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[PubMed: 6308033] 99

The upregulation of the CPT gene increases mitochondrial ROS and results in the death of CD4 + T cells

5.4 Gaps in current knowledge and future directions While genomic plasticity contributes to resistance, the precise evolutionary trajectory of resistant Leishmania strains under drug pressure remains unclear, necessitating longitudinal studies to track genomic changes in response to treatment (Santi and Murta, 2022)