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Sirtuin 1 (SIRT1) activation mediates sildenafil induced delayed cardioprotection against ischemia-reperfusion injury in mice

1 Introduction Bioactive compounds present in various food matrices and medicinal plants are gaining increasing relevance in human health, as recent research has shown that they can aid in the treatment and delay the onset of chronic diseases (1, 2)

The use of hepatic protectants such as S-adenosyl-Lmethionine (SAMe) and N-acetylcysteine (NAC), monitoring hepatic parameters for a minimum of 2 to 3 days, and providing supportive care are necessary for a positive outcome in overdose situations

This intervention however did not show to avert animals cachexia