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Clinical course The clinical course of APAP hepatotoxicity in patients with a single overdose can be classically divided into 4 sequential stages (table below ), however, it should be noted that the course is variable and may not follow the four-stage sequential pattern seen after a single oral ingestion

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Often, a few weeks of therapy will markedly improve symptoms related to chronic disease and allow for the transition to appropriate oral supplements.IV therapy with nutrients may be needed only a few times or twice weekly for an extended period