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Furthermore, the article indicates that specifically inducing ferroptosis in rice can restrict the invasive growth of Magnaporthe oryzae , thus enhancing resistance to the rice blast disease ( Another study discovered that with increasing age, the levels of ferrous iron (Fe 2+ ) rise and glutathione (GSH) levels decline in Caenorhabditis elegans , and this imbalance promotes the occurrence of ferroptosis

Additionally, DA quinones can be oxidized to aminochrome, whose redox-cycling leads to the generation of the superoxide radical and the depletion of cellular nicotinamide adenine dinucleotide phosphate-oxidase (NADPH), which ultimately forms the neuromelanin (Sulzer et al., 2000) known to be accumulated in the SNpc of the human brain (Ohtsuka et al., 2013, 2014

It is an important pathogenic mechanism in metabolic diseases or fatty liver, and may become a key direction for improving MASLD

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