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It is transported through SLC38A1 in CD4 + T cells and TCR stimulation induces its expression ( Glutamine is the most abundant amino acid in the serum ( Slc1a5 -/- CD4 + T cells do not affect TCR-mediated activation, deletion of Slc1a5 impaired Th1 and Th17 cell differentiation ( Figure 1 ) ( Arginine is transported through cationic amino acid transporters (CAT) ( These findings demonstrate distinct roles for amino acid transporters in TCR/CD3-mediated T cell stimulation, differentiation, and function and indicate that manipulation of these transporters could serve therapeutic approaches for autoimmune diseases including SLE ( Figure 1 )