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However, further mechanistic studies are needed to determine the direct effects of choline availability on eosinophil activation and function and to assess the therapeutic potential of dietary choline supplements (95) in managing hyperreactive eosinophilic conditions, such as eosinophilic myositis or gastrointestinal disorders

Therefore, intracellular GSH depletion or GPX4 inactivation induced by various factors will decrease the clearance rate of toxic lipid peroxides and result in ferroptosis

doi: 10.1016/j.bjid.2015.10.011 219 MullallyC

Thus, the redox status of SENP3 is a decisive factor for its stabilization or degradation [158] and can regulate the expression of the EMT-inducing transcription factor fork head box C2 (FOXC2) that is de-SUMOylated and thereby activated in response to increased ROS levels