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doi: 10.1016/j.freeradbiomed.2013.05.001 138 SmirnoffN

However, most of these nonspecific activators affect multiple target proteins in addition to SIRT1, and the specific downstream pathways through which SIRT1 protects the cochlea following noise exposure have not yet been fully elucidated

6 Limitation and future research priorities Despite the promising potential of ferroptosis-targeting therapies, several limitations currently hinder their translation into clinical practice