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[DOI] [PMC free article] [PubMed] [Google Scholar] 127.Nath C.E., Shaw P.J

The biological relevance of this phenomenon is essential since several opsonizing proteins (such as complement factors, coagulation factors, and immunoglobulins) rely on conformational changes in order to activate their respective signaling cascades, and otherwise, some di per se non-immunogenic proteins may expose new epitopes that can trigger subsequent opsonization

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