In imiquimod-induced mouse models, betulin-loaded NLCs produced marked lesion improvement accompanied by reductions in systemic inflammatory cytokines such as TNF-, IL-6, and IL-17, along with a lowered spleen index, indicating that their therapeutic benefit extends beyond local skin improvement to systemic immunomodulation [123, 124]
Omega-3 fatty acid supplementation in severe brain trauma: case for a large multicenter trial
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A systematic review and meta-analysis involving 42,041 patients further confirmed that nearly half of CKD patients exhibit sarcopenia, with an even higher prevalence among dialysis patients (43)
