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Though adverse effects with the use of acetaminophen are uncommon with therapeutic dosing, overdosage of acetaminophen can cause clinically significant hepatic necrosis, which may progress to fulminant hepatic failure

Next, Phaser and RESOLVE (Terwilliger, 2000) were employed to assist in resolution of the hand ambiguity

did consider [4Fe4S] clusters formed by a capped molecule of cysteine (N-acetyl-L-cysteine-N-methylamide), in which the charges on the amino and carboxylate groups are eliminated by acetylation and methylamidation, respectively, giving a non-charged coordination environment similar to peptides