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doi: 10.3389/fphar.2024.1472670 Received 29 July 2024 Accepted 04 December 2024 Published 18 December 2024 Volume 15 - 2024 Edited by Md Saquib Hasnain, Palamau Institute of Pharmacy, India Reviewed by Mamunur Rashid, University of Nebraska Medical Center, United States Munkhtuya Tumurkhuu, Wake Forest Baptist Medical Center, United States Updates Copyright 2024 Lupu, Miron, Trandafir, Jechel, Starcea, Ioniuc, Frasinariu, Mocanu, Petrariu, Danielescu, Nedelcu, Salaru, Revenco and Lupu

Exposure to aspartame at high concentrations (up to 10 mM) reduced metabolic activity (measured by the MTT assay) in Caco-2 cells, a human epithelial cell line derived from a colon carcinoma