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Nonetheless, the study identified a clear trend of more prevalent metabolic vitamin B 12 deficiency (measured as cB 12 ) with increasing age (Risch et al., 2015)

The latter can be caused by complete or partial deficiency of the enzyme methylmalonylCoA mutase, which requires vitamin B12 as a co-factor (5deoxy-adenosyl-cobalamin (AdoCbl)) (Figure 22b.7)

Because the nutrients are delivered directly into the bloodstream, the body can absorb and utilize them more efficiently than with oral supplements

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