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Description

Necrotic concentrations of cisplatin activate the apoptotic machinery but inhibit effector caspases and interfere with the execution of apoptosis

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Under hypoxic conditions, cancer cells uniformly activate a transcriptional program mediated by hypoxia-inducible factors (HIF-1 and HIF-2) 96

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These models lack the matrix and immune cells essential for regulating cell behaviors, such as differentiation, survival, proliferation, and migration, making it impossible to accurately simulate the organ structure (55)

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