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Funding This work was supported by the Guangdong Basic and Applied Basic Research Foundation (NO.2023A151501010104)

During the reperfusion phase, oxidative stress induces surplus H 2 O 2 which is converted to hydroxyradicals by the Fenton reaction within lysosomes

Recent experiments have shown that vitamin D is also an antioxidant (27)

ACKNOWLEDGMENTS The authors would like to thank ICF staff members (Angelina Winnett, Andrew Maresca, Wren Tracy, and Ruby Carter-Ogen) and Prometheus Federal Services staff members (Marimac Clearfield, Allison Schwedock, Diane Boyd, and Kimberly Lopez) for their assistance in screening studies, creating figures and Tableau visualizations, and document production