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doi: 10.3389/fphar.2022.998179 Received 19 July 2022 Accepted 17 August 2022 Published 06 October 2022 Volume 13 - 2022 Edited by Tariq Ismail, Comsats University Islamabad, Pakistan Reviewed by Marcelino Maneiro, University of Santiago de Compostela, Spain Aisha Ayaz, Combined Military Hospital, Pakistan Updates Copyright 2022 Bulama, Nasiru, Bello, Abbas, Nasiru, Saidu, Chiroma, Mohd Moklas, Mat Taib, Waziri and Suleman

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Results from the co-treatment with Fer1, a ferroptosis inhibitor, and ZVAD, an apoptosis inhibitor, indicate that RSL3 effects were reversed by Fer1 but not by anti-apoptotic ZVAD

Iron overload is essential for ferroptosis execution ( 3+ ) that bind to transferrin (TF) are transported into cells via transferrin receptor (TFRC)