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All image acquisition and analyses were performed in a blinded manner

Peer review Peer review information Nature Communications thanks Yigong Shi, Brian Sutton and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

This strategy aims to replicate the appearance and mechanical functions of the native disc

In fact, in the case of lysozyme, the rapid glutathionylation of Cys94 stops completely the deleterious aggregation at pH 7.4 2 , while the glutathionylation of Cys1 in rChTg at this pH could not be detected due to a too fast protein aggregation (data not shown)