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Matsui H, Einama T, Shichi S, et al

Stones larger than 10 mm or that do not respond to conservative treatment may be treated with lithotripsy, ureteroscopy, or rarely, open surgery (Antonelli 2015)

Pharmacology [edit] Pharmacodynamics [edit] Although the mechanism of action of valproate is not fully understood, [38] traditionally, its anticonvulsant effect has been attributed to the blockade of voltage-gated sodium channels and increased brain levels of the inhibitory synaptic neurotransmitter gamma-aminobutyric acid (GABA)