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Ligand coordinates and restraints were generated by using Phenixs eLBOW and modelled accordingly based on the observed diffraction data

Under normal physiological conditions, excess free radicals produced by brain metabolism can be cleared by endogenous antioxidants such as superoxide dismutase (SOD) and glutathione (GSH), maintaining a balance between ROS production and elimination [56]

Chest pain, shortness of breath, tremor, and dysuria have all been described following methylene blue administration [8]

These changes create self-reinforcing pathological cycles that worsen tissue function and promote systemic insulin resistance ( AT comprises distinct depots (white, brown, beige, and pink) with unique physiological functions and metabolic characteristics ( At the molecular level, adipose dysfunction involves cellular stress responses, aberrant inflammatory signaling, and dysregulated microRNA networks