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It is worth mentioning that in addition to the lungs, moderate continuous or interval exercise (treadmill running, 5 times/week, 4 weeks) in type 2 diabetic rats upregulates compensatory antioxidant capacity to achieve a more favorable redox balance in the liver [78]

Specifically, overexpressed GPX3 induced mitochondrial dysfunction and cytoplasmic transfer of Cyto-C through up-regulation of BAX and down-regulation of Bcl-2, and ultimately induced mitochondria-dependent apoptosis via the caspase 9-caspase 3 cascade, and then cooperated with the blocking effect of GPX3 on G0/G1 phase to attenuate the proliferation activity of prostate cells

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