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In living cells, it is derived from glutathione through the action of an enzyme, -glutamyl cyclotransferase

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54 HuangL.-C.LaiU.-L.YangS.-F.ChuM.-J.KuoC.-I.TsaiM.-F.et al (2007)

Molecular mechanisms underlying protein glycation The molecular mechanism underlying the extracellular glycation process starts with the reaction between a primary amino group of a protein (i.e., the N-terminal -amino group or the -amino group of Lys residues), and the carbonyl group of glucose