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Current research models use 812 week cycles followed by 46 week breaks to prevent metabolic adaptation, though long-term human data is limited

Different pathological patterns of white matter injury reflect different pathogenetic mechanisms of myelin and oligodendrocyte damage Although pathogenetic events that target myelin and oligodendrocytes invariably result in primary demyelination, the structural patterns of tissue injury in the initial stages of lesion formation differ, depending upon the mechanism involved

Patients seeking weight loss treatment should not attempt to calculate or self-administer doses of any unlicensed injectable compound

Suvarna KS, Layton C, Bancroft JD (2013) Bancrofts theory and practise of histological techniques, 7th edn