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Prostaglandin E1 plus methylcobalamin combination therapy versus prostaglandin E1 monotherapy for patients with diabetic peripheral neuropathy: a meta-analysis of randomized controlled trials

When in doubt, treat the transaction the way you would a prescription drug, because that is what it is

This is a commonly referenced study from 1963 claiming a half-life of 5-6 days: nature.com/articles/198200a0 Although I would not cite it as an authority, the six-day half-life has also made it onto the B12 page in Wikipedia, seemingly unchallenged

Deficiency Signs: - Hair loss or brittle hair - Hair damage or breakage - Dry, irritated skin - Weak or brittle nails - Cramps and tingling in the limbs - Digestive issues Recommendations: (if only for skin, hair and nails) once a week until desired results are achieved