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For example, LAT1 has been shown to exhibit a high maximal transport capacity (Vmax 4060 nmol/min/g) and a substantial binding affinity (Km 10200 M), enabling the rapid exchange of high-affinity substrates across the BBB with half-times (half the time required to reach drug concentration equilibrium between the brain and blood) under 15 min [83]

329 The ability of sHSPs to engage a wide range of aggregation-prone proteins, coupled with their rapid upregulation in response to cellular stress, positions them as critical first responders in neurodegenerative proteostasis

This characteristic is especially beneficial in emergency situations or for conditions requiring immediate relief, such as acute pain or migraines

The fruit also contains some, but it's less potent