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2-amino-3-hydroxypyridine

Infection usually begins with an expanding skin lesion, known as erythema migrans (referred to as stage 1), which, if untreated, can be followed by early disseminated infection, particularly neurological abnormalities (stage 2), and by late infection, especially arthritis in North America or acrodermatitis chronica atrophicans in Europe (stage 3)

Co-administration of NSO with gliclazide significantly increased systemic exposure to gliclazide, as evidenced by a 29% enhancement in its bioavailability

This modification particularly targets key enzymes in amino acid metabolism pathways, such as 10-formyltetrahydrofolate dehydrogenase, in one-carbon metabolism