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Genetic counseling should be considered, particularly in consanguineous populations where homozygous or compound heterozygous mutations are more prevalent

doi: 10.1126/sciadv.aau8857 36 Diaz-LagaresA.Mendez-GonzalezJ.HervasD.SaigiM.PajaresM

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However, X-Pro peptide groups tend to have a roughly 30:1 ratio, presumably because the symmetry between the C and C atoms of proline makes the cis and trans isomers nearly equal in energy, as shown in the figure below