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170, no

If the question is about repeated signaling, split administration may make more sense than a one-time daily exposure

The in vitro experiment also revealed acrolein adduction to Arg-307, forming six-membered heterocycle

NADPH oxidase- generated O 2 , besides NO scavenging, triggers eNOS uncoupling (the mechanisms are discussed in the next section), and uncoupled eNOS becomes itself a source of superoxide [19]