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We also targeted the accumulation of late life iron 2, 16 , that catalyses (phospho)lipid hydroperoxide propagation, using salicylaldehyde isonicotinoyl hydrazone (SIH, 250 M), a lipophilic acylhydrazone that scavenges intracellular iron and mobilizes it for extracellular clearance 24

Targeted metabolomics in HeLa cells expressing Lb NOX ( a ), Ec STH ( b ) and mito Ec STH ( c )

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However, from detailed genetic mapping of the relationships between various regions in primary tumours and across metastatic sites in different cancer types, a far more complexeven chaoticpicture has emerged