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However, it is important to note that curcumin has also been identified as a PAINS, exhibiting behaviors such as redox cycling, metal chelation, aggregation, and fluorescence interference that can artificially inflate its apparent bioactivity in vitro (Nelson et al., 2017)

Editor: Salik Hussain, National Institutes of Health, UNITED STATES Received: December 22, 2016

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In RA compared with healthy tissue, synovial fibroblasts undergo a metabolic shift associated with increased invasive capacity and disease activity