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Description

2016;4(1):e12672

Structural analyses reveal tight interactions between L-phosphoserines phosphate group and conserved arginine (Arg42, Arg328) and histidine (His41, His327) residues, suggesting that analogs targeting these residues could yield potent inhibitors (77)

What is now required are more clinical trials to confirm or disprove these preliminary findings together with closer ties between non-clinical and clinical research to forge a link between molecular mechanisms and therapeutic outcomes