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Degranulation of human lung MCs has been shown to be inhibited in coculture with bronchial epithelial cells ( in vivo as well as MC degranulation and cytokine release were decreased by lipoxin B4 application ( Figure 1 One major class of allergen-containing particles represent plant pollens, where pollen grains are coated with different lipids essential for plant fertilization ( Ambrosia artemisiifolia ( Ambrosia pollen extract induces histamine release by a ROS-dependent mechanisms, but not -hexosaminidase release ( Juniperus ashei ) pollen extract, release of both serotonin and -hexosaminidase was induced in RBL cells in an IgE-independent, but ROS-dependent manner

Those signaling pathways were considerably activated in HUVECs incubated with the CM of ELF3overexpressed EOC cells and remarkably attenuated in HUVECs cultured in the CM of ELF3silenced EOC cells compared with the controls (Figs 4F and EV2D)

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