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Applying a cream containing GHK-Cu to the facial skin of 71 women with mild to late signs of photoaging for 12 weeks can increase skin density and thickness, reduce sagging, improve transparency, and reduce the depth of fine lines and wrinkles

The K1 Cagri rotamer resides in a similar position to the non-acylated K1 rAmy 15 , and this contrasts with the orientation observed in the Cagri-AMY 1 R-Gs complex