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As discussed above, the biosynthetic pathway leading to AsA production is very hard to crack, and only in very few cases, over a large number of attempts, AsA content in tomato fruit was raised up to a level that could, at least in theory, be used for the needs of human nutrition ( GULO ), encoding the enzyme still present in the animal biosynthetic pathway, was lost in early photoautotrophs and replaced by l -GalLDH in the Archaeplastida lineage, but also in some non-photosynthetic organisms that have lost their plastids

GSSG accumulation of this magnitude can be observed in catalase-deficient plants following transfer to oxidative stress conditions

Even more promising, follow-up data showed continued symptom relief 2 years after treatment

Epub 2018 Feb 23