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First-pass-Effekt bedeutet, dass ein Anteil resorbierter Substanz bei der ersten Leberpassage umgewandelt oder eliminiert wird

doi:10.1371/journal.pone.0107369 Egiebor E, Tulu A, Abou-Zeid N, Oseji OF, Ishaque AB

The suggestion to consider a treatment with topical PDT is often restricted, i.e., in the case of nBCC, to thin (2 mm) nBCC, because the ability to penetrate both the prodrug and light decreases with the growing depth of the BCC lesion [153]