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Other candidate molecules with high variability in the Senegalese population included the SLC transporter SLC40A1 (Ferroportin), in which the Q248H mutation has recently been reported to be positively selected to protect against severe malaria 33 , and amino acid or nucleobase transporter SCL43A3 34,35

These results support the notion that enhanced GST-mediated conjugation represents a key mechanism contributing to CF resistance in recurrent EC and highlight the potential value of evaluating multiple GST genes rather than a single marker