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Last updated on Dec 28, 2025

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[12] Another active metabolite, norendoxifen (4-hydroxy- N , N -didesmethyltamoxifen), is formed via N -demethylation of endoxifen or 4-hydroxylation of N , N -didesmethyltamoxifen

Therefore, presenting with the normalized pressures in the BPC 157-rats, abrogated organs lesions and counteracted thrombosis, these activated shunts represent the rapidly established alternative equilibrium, which is well functioning (i.e., consistently maintained undisturbed blood pressure in the superior sagittal sinus) in the compensation of the otherwise harmful conditions of the central venous occlusion