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As disease onset neared, microglia expressed increased chemokine (CC motif) ligand 2 and other chemotaxis-associated molecules, which are involved in the recruitment of monocytes to the CNS by spinal cordderived microglia

doi: 10.1056/NEJMoa2103629 128 AndersenAMLeiMKBeachSRHPhilibertRASinhaSColganJD

Platelet hyperactivity, increased prothrombotic coagulation factor activity, and impaired fibrinolysis are the main causes of an elevated thrombotic tendency in the context of low-grade chronic inflammation

Upon binding to its ligands, PD-1 inhibits T cell function, reduces T cell proliferation, and promotes immune tolerance [108]