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The formation of ice crystals can physically shred them

Preclinical PTSD models consistently implicate gut barrier dysfunction, immuneinflammatory activation, HPA axis dysregulation and neurotransmitter imbalance as key mechanistic through-lines (Sherin and Nemeroff, 2011

Erythrocytes play a crucial role in the regulation of eNOS-derived nitric oxide (NO) bioavailability, acting as scavengers of this critical vasodilator with an effect on vascular tone and blood flow [45]