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Mechanism of Action: The "Push-Pull" Effect

This Introduction sets the conceptual framework for the rest of the work and justifies the need for diagnostic and therapeutic strategies that account for source, compartment and context specificity in ROS signaling

In macrophages, scoparone can alleviate lipopolysaccharide-induced immune responses partly by blocking TLR-4/NF-B signaling, and regulate autophagy by inhibiting the ROS/P38/Nrf2 axis