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Dr Shah-Desai outlines them below: Niacinamide "Niacinamide is a powerful antioxidant that enhances the prevention of pigmentation, improves the lightening effect on brown spots, and works in synergy with tranexamic acid for visible improvements of dark circles." Vitamin C "A stabilised form of vitamin C will help provide powerful antioxidant benefits and also delivers a brightening effect on pigmentation and dark spots." Caffeine "In addition to providing antioxidant benefits, caffeine is a vasoconstrictor and can provide a shrinking effect on the diameter of blood vessels, which in turn can lead to a decrease in dark circles, fine lines and puffiness around the eyes." Tranexamic Acid "Tranexamic acid inhibits UV-induced melanin synthesis by blocking the interaction between keratinocytes and melanocytes and ensures that long term accumulative results are not compromised by UV exposure." Natural Arbutin "This ingredient strongly inhibits tyrosinase activity, which is the key enzyme of the pigmentation process

In: Environmental Pollutants and Their Bioremediation Approaches (2020), 14568

It is almost exclusively contained in animal products such as meat and dairy

NMPA wants contract manufacturers to prioritize cooperation with MAHs that possess independent research and development management capabilities and master of key process technologies of the contracted products. MAHs and contract manufacturers should strengthen risk identification, communication, and analysis when transferring products for outsourcing